Leukemias With a t(1;19)(q23;p13): A Pediatric Oncology Group Study Predictive of Treatment Outcome in Childhood Acute Lymphoblastic Chimeric Transcript Status at End of Consolidation Is Not E2A-PBX1
نویسندگان
چکیده
Cleary Lauer, Donald H. Mahoney, D. Jeanette Pullen, Jonathan J. Shuster, C. Philip Steuber and Michael L. Stephen P. Hunger, Majilinde Z. Fall, Bruce M. Camitta, Andrew J. Carroll, Michael P. Link, Stephen J. Leukemias With a t(1;19)(q23;p13): A Pediatric Oncology Group Study Predictive of Treatment Outcome in Childhood Acute Lymphoblastic Chimeric Transcript Status at End of Consolidation Is Not E2A-PBX1
منابع مشابه
E2A-PBX1 chimeric transcript status at end of consolidation is not predictive of treatment outcome in childhood acute lymphoblastic leukemias with a t(1;19)(q23;p13): a Pediatric Oncology Group study.
A t(1;19)(q23;p13) is detected cytogenetically in approximately 5% of childhood acute lymphoblastic leukemias (ALLs) and its presence has been associated with an increased risk of relapse in several previously-completed Pediatric Oncology Group (POG) clinical trials. The t(1;19) fuses E2A to PBX1 in more than 95% of cases and this molecular abnormality can be reliably identified by polymerase c...
متن کاملThe t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias.
The t(1;19)(q23;p13) chromosomal translocation is observed cytogenetically in 25% of children with pre-B-cell acute lymphoblastic leukemia (ALL) and is associated with an adverse treatment outcome. The t(1;19) juxtaposes the E2A gene from chromosome 19 with the PBX1 gene on chromosome 1, leading to the production of fusion transcripts and resultant chimeric proteins that contain the transcripti...
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The t(1;19)(q23;p13) is the most common recurring chromosomal translocation in childhood acute lymphoblastic leukemia (ALL) and has been associated with adverse prognosis. It involves the rearrangement of two genes, PBXl and E2A. resulting in the production of transforming chimeric DNAbinding proteins. In all previous reports in which the presence of a chimeric transcript was described, the fus...
متن کاملMonoclonal antibodies specific to the acute lymphoblastic leukemia t(1;19)-associated E2A/pbx1 chimeric protein: characterization and diagnostic utility.
Nonrandom chromosomal abnormalities are found in most human malignancies, particularly leukemias and lymphomas. A characteristic t(1;19) (q23;p13.3) chromosomal translocation is detected in 5% of childhood acute lymphoblastic leukemia (ALL) cases. This translocation results in the formation of a fusion gene, which leads to the expression of an oncogenic E2A/pbx1 protein. Breakpoints in the E2A ...
متن کاملDifferent molecular consequences of the 1;19 chromosomal translocation in childhood B-cell precursor acute lymphoblastic leukemia.
The prognostically important 1;19 chromosomal translocation can alter the E2A gene on chromosome 19p13 in childhood B-cell precursor acute lymphoblastic leukemia (ALL), leading to formation of a fusion gene (E2A-PBX1) that encodes a hybrid transcription factor with oncogenic potential. It is not known whether this molecular alteration is a uniform consequence of the t(1;19) or is restricted to ...
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